Hydrochloric Acid → HCID 58237059, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-fluoro-2-(1-methylethoxy)-1-nitrobenzene (20.34 g) in dimethylsulfoxide (150 mL) was added 20% aqueous sodium hydroxide solution (68 mL) at room temperature and the mixture was stirred at 60° C. for 3 h. The mixture was cooled to room temperature and 6M hydrochloric acid (50 mL) was added to the mixture. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, filtered and concentrated. The residual oil was solidified with hexane to give the title compound (14.94 g, 74%) as a yellow solid.

Provenance & Evidence