Ethanol → HCID 67118502, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[3-(1-methylethoxy)-4-nitrophenoxy]-5-(methylsulfonyl)pyridine (39.89 g), iron powder (31 g), calcium chloride (1.3 g), ethanol (400 mL) and water (100 mL) was stirred at 80° C. for 3 h. The mixture was filtered through celite and the filtrate was concentrated under reduced pressure. Water and brine were added to the residue. The mixture was extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, filtered and concentrated. The residual solid was washed with diethyl ether-hexane to give the title compound (32 g, 88%) as a brownish solid. MS 323 (MH+).

Provenance & Evidence