Potassium Carbonate → HCID 58237034, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(benzyloxy)-4-fluoro-1-nitrobenzene (21.0 g), 6-(methylsulfonyl)pyridin-3-ol (14.7 g) and potassium carbonate (12.2 g) in N,N-dimethylformamide (130 mL) was stirred at 90° C. for 5 h and then at 60° C. for 15 h. The reaction mixture was concentrated and the residue was partitioned between ethyl acetate and aqueous citric acid. The organic layer was washed successively with water and brine, dried (MgSO4), filtered, and concentrated to give light yellow crystals, which were washed with ethyl acetate-hexane to give the title compound (28.0 g, 82%) as pale yellow crystals. MS 401 (MH+).

Provenance & Evidence