HCID 58237077, compound → HCID 67118481, compound

Participants

Reaction Steps

To a solution of 2-(benzyloxy)-4-{[6-(methylsulfonyl)pyridin-3-yl]oxy}aniline (26 g) in a mixture of tetrahydrofuran (200 mL) and methanol (50 mL) was added palladium on carbon (5 g, 10 wt %, wet), and the mixture was stirred at room temperature for 5 h under hydrogen atmosphere. The mixture was filtered to remove the catalyst and the filtrate was concentrated under reduced pressure. The residual oil was solidified with diethyl ether, and the solid was washed with ethyl acetate-diethyl ether to give the title compound (17.28 g, 88%) as a grayish solid. MS 281 (MH+).

Provenance & Evidence