Sodium Hydroxide → HCID 66898145, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 7-methoxy-5-{[5-(methylsulfonyl)pyridin-2-yl]oxy}-1H-indole-2-carboxylate (2.78 g) in a mixture of tetrahydrofuran (25 mL) and ethanol (20 mL) was added 1M aqueous sodium hydroxide solution (11 mL), and the mixture was stirred at 50° C. for 40 min. The mixture was concentrated under reduced pressure. The residue was dissolved in water, and 1M hydrochloric acid (11 mL) was added to the mixture. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, filtered and concentrated. The residual oil was solidified with diethyl ether to give the title compound (2.18 g, 81%) as a pale orange solid. MS 363 (MH+).

Provenance & Evidence