Ammonium Hydroxide → HCID 66898156, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7-methoxy-5-{[5-(methylsulfonyl)pyridin-2-yl]oxy}-1H-indole-2-carboxylic acid (2.18 g), N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride (2.3 g), 1-hydroxybenzotriazole (1.6 g) and N,N-dimethylformamide (20 ml) was stirred at 50° C. for 25 min. The mixture was cooled to room temperature, and 10% aqueous ammonium hydroxide solution (3 mL) was added to the mixture. After stirring at room temperature for 2 days, the mixture was concentrated under reduced pressure. Water was added to the residue and the mixture was extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine, dried over magnesium sulfate, filtered and concentrated to give the title compound (2.09 g, 96%) as an orange oil. MS 362 (MH+).

Provenance & Evidence