Lawesson's reagent → HCID 86652847, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 7-methoxy-5-{[5-(methylsulfonyl)pyridin-2-yl]oxy}-1H-indole-2-carboxamide (2.1 g) in tetrahydrofuran (400 mL) was added Lawesson's reagent (2.3 g) and the mixture was stirred at 60° C. for 50 min. The mixture was concentrated under reduced pressure and the residue was dissolved in ethyl acetate. The mixture was washed with saturated brine, dried over magnesium sulfate, filtered and concentrated. The residue was solidified with ethyl acetate and the resulting solid was washed with diethyl ether to give the title compound (2.06 g, 94%) as a pale yellow solid. MS 378 (MH+).

Provenance & Evidence