Sodium Hydroxide → HCID 66897332, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 7-[2-methoxy-1-(methoxymethyl)ethoxy]-5-{[5-(methylsulfonyl)pyridin-2-yl]oxy}-1H-indole-2-carboxylate (3.42 g) in a mixture of tetrahydrofuran (20 mL) and ethanol (15 mL) was added 1M aqueous sodium hydroxide solution (18 mL), and the mixture was stirred at 50° C. for 50 min. The mixture was concentrated under reduced pressure and the residue was dissolved in water. The mixture was washed with diethyl ether. To the aqueous layer was added 1M hydrochloric acid (18.5 mL) and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, filtered and concentrated. The residual amorphous solid was solidified with diethyl ether to give the title compound (1.66 g) as a pale yellow solid. MS 553 (MH+).

Provenance & Evidence