Lawesson's reagent → HCID 86652849, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 7-methoxy-5-{[6-(methoxymethyl)pyridin-3-yl]oxy}-1H-indole-2-carboxamide (1.86 g) in tetrahydrofuran (40 mL) was added Lawesson's reagent (2.3 g), and the mixture was stirred at 50° C. for 2 h. The mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate and the mixture was washed with saturated brine, dried over magnesium sulfate, filtered and concentrated. The residue was purified by basic silica gel column chromatography (ethyl acetate/hexane=30/70 to 90/10, volume ratio) to give the title compound (2.04 g, 100%) as a yellow amorphous solid. MS 344 (MH+).

Provenance & Evidence