1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 58237016, compound

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Reaction Steps

To a solution of 7-(2-methoxy-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-1H-indole-2-carboxylic acid (1.072 g) in N,N-dimethylformamide (15 mL) were added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.98 g) and 1-hydroxybenzotriazole ammonium salt (0.788 g) at room temperature. The mixture was stirred at room temperature for 1 h. The mixture was concentrated in vacuo. Water and ethyl acetate were added to the residue and the resultant was extracted with ethyl acetate. The organic layer was washed successively with brine and water, dried (MgSO4), filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography (ethyl acetate: methanol=100:0 to 95:5, volume ratio) to give the title compound. (910 mg, 85%) as a white amorphous solid. MS 419 (MH+).

Provenance & Evidence