Methanol → HCID 58236987, compound

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Reaction Steps

To a mixture of ethyl 6-fluoro-7-[(methylsulfonyl)oxy]-5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-1H-indole-2-carboxylate (3.1 g), tetrahydrofuran (25 mL) and methanol (25 mL) was added a solution of potassium hydroxide (85%, 1.9 g) in water (15 mL). The mixture was stirred at room temperature for 15 h and then concentrated in vacuo. The residue was partitioned between ethyl acetate and aqueous citric acid solution. The organic layer was washed with brine, dried (MgSO4), filtered, and concentrated to give a light pink solid, which was washed with ethyl acetate-hexane to give the title compound (2.52 g, 100%) as a light pink solid. MS 365 (MH+).

Provenance & Evidence