Lawesson's reagent → HCID 86652850, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-fluoro-7-(2-methoxyethoxy)-5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-1H-indole-2-carboxamide (0.61 g) and Lawesson's reagent (0.61 g) in tetrahydrofuran (25 mL) was stirred at 55° C. for 2 h. The reaction mixture was concentrated in vacuo. The residue was purified by silica gel chromatography (ethyl acetate:hexane=40:60 to 70:30, volume ratio) to give light yellow crystals, which were washed with ethyl acetate-hexane to give the title compound (585 mg, 92%) as light yellow crystals. MS 440 (MH+).

Provenance & Evidence