Potassium Hydroxide → HCID 58237054, compound

Participants

Reaction Steps

To a stirred solution of ethyl 7-methoxy-5-[4-(methylsulfonyl)phenoxy]-1H-indole-2-carboxylate (0.93 g) in tetrahydrofuran (15 mL) and methanol (15 mL) was added a solution of potassium hydroxide (85%, 0.50 g) in water (10 mL). The mixture was stirred at room temperature for 15 h and then concentrated in vacuo. The residue was partitioned between ethyl acetate and aqueous citric acid solution. The organic layer was washed with brine, dried (MgSO4), filtered, and concentrated to give a light yellow amorphous solid, which was crystallized from ethyl acetate-hexane to give the title compound (783 mg, 91%) as pale yellow crystals. MS 362 (MH+).

Provenance & Evidence