HCID 68381586, compound → HCID 67118499, compound

Participants

Reaction Steps

Ethyl (2-{7-[(1-methyl-1H-imidazol-2-yl)methoxy]-5-[4-(methylsulfonyl)phenoxy]-1H-indol-2-yl}-4,5-dihydro-1,3-thiazol-5-yl)acetate (1 g) was dissolved in a mixed solvent of tetrahydrofuran (10 mL)-ethanol (10 mL), 1M aqueous sodium hydroxide solution (5 mL) was added, and the mixture was stirred at room temperature for 1 hr. The reaction solution was concentrated under reduced pressure. Water was added to the residue, and the mixture was neutralized with 1M hydrochloric acid. The mixture was washed with ethyl acetate, and the aqueous layer was concentrated under reduced pressure. Ethanol was added to the residue, and the insoluble substance was filtered off. The filtrate was concentrated, and the obtained yellow solid was recrystallized from ethanol to give the title compound (170 mg) as yellow crystals. MS 541 (MH+).

Provenance & Evidence