Sodium Hydroxide → HCID 67118679, compound

Participants

Reaction Steps

Ethyl [2-(7-methoxy-5-{[6-(methoxymethyl)pyridin-3-yl]oxy}-1H-indol-2-yl)-4,5-dihydro-1,3-thiazol-5-yl]acetate (1.36 g) was dissolved in a mixture of tetrahydrofuran (15 mL) and ethanol (15 mL). To the mixture was added 1M aqueous sodium hydroxide solution (5 mL) and the mixture was stirred at room temperature for 30 min. The mixture was concentrated under reduced pressure. The residue was dissolved in water and the mixture was neutralized with 1M hydrochloric acid. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, filtered and concentrated to give the title compound (1.30 g, 100%) as a yellow amorphous solid. MS 428 (MH+).

Provenance & Evidence