Tetrahydrofuran → HCID 58237049, compound

Participants

Reaction Steps

To a mixture of ethyl (2-{7-(2-methoxy-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-1H-indol-2-yl}-4,5-dihydro-1,3-thiazol-5-yl)acetate (134 mg), tetrahydrofuran (1 mL) and ethanol (1 mL) was added 1M aqueous sodium hydroxide solution (0.51 mL). The whole was stirred at room temperature for 2 h, and then concentrated in vacuo. The residue was acidified by 1M hydrochloric acid, and then extracted with ethyl acetate-tetrahydrofuran. The organic layer was washed successively with water and brine, dried (MgSO4), filtered, and concentrated in vacuo to give the title compound (57 mg, 43%) as a yellow amorphous solid. MS 519 (MH+).

Provenance & Evidence