1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 58237047, compound

Participants

Reaction Steps

To a solution of (2-{7-(2-methoxy-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-1H-indol-2-yl}-4,5-dihydro-1,3-thiazol-5-yl)acetic acid (48 mg) in N,N-dimethylformamide (2 mL) were added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (35 mg) and 1-hydroxybenzotriazole ammonium salt (28 mg) at room temperature. The mixture was stirred at room temperature over night. The mixture was concentrated in vacuo. Ethyl acetate was added to the residue and the resultant was washed with water, dried (MgSO4), filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography (ethyl acetate:methanol=100:0 to 90:10, volume ratio) to give the title compound. The compound was triturated and washed with diethyl ether-ethyl acetate-hexane to give the title compound (11 mg, 23%) as a white powder. mp 107-112° C.

Provenance & Evidence