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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1189034Generated: November 2, 2026

Hydrochloric Acid → HCID 67118476, compound

https://huagongshe.com/reaction/1189034

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantTetrahydrofuranHCID 8028—
ReactantSodium HydroxideHCID 14798—
ReactantHCID 66897908HCID 66897908—
SolventEthanolHCID 702—
SolventWaterHCID 962—
ProductHCID 67118476HCID 6711847693%

Reaction Steps

A mixture of ethyl {2-[7-(2-methoxy-1-methylethoxy)-5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-1H-indol-2-yl]-4,5-dihydro-1,3-thiazol-5-yl}acetate (580 mg), tetrahydrofuran (3 mL), ethanol (3 mL) and 1M aqueous sodium hydroxide solution (3 mL) was stirred at room temperature for 4 h. Water and 1M hydrochloric acid (3 mL) were added to the mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried (MgSO4), filtered, and concentrated in vacuo to give the title compound (510 mg, 93%) as a brown amorphous solid. MS 520 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673942B2
Source datasetuspto-grants-2014_03
ORD IDord-39c180eaf8e34aed9cad08f04dbdbd4b
Source noteuspto-grants-2014_03