Methanol → HCID 58237013, compound

Participants

Reaction Steps

To a mixture of ethyl (2-{7-methoxy-5-[4-(methylsulfonyl)phenoxy]-1H-indol-2-yl}-4,5-dihydro-1,3-thiazol-5-yl)acetate (0.42 g), tetrahydrofuran (8 mL) and methanol (8 mL) was added a solution of potassium hydroxide (85%, 0.25 g) in water (5 mL). The mixture was stirred at room temperature for 15 h and concentrated. The residue was partitioned between ethyl acetate and water. The organic layer was washed with brine, dried (MgSO4), filtered, and concentrated to give a light amorphous solid, which was crystallized from ethyl acetate-hexane to give the title compound (340 mg, 86%) as pale yellow crystals. MS 461 (MH+). mp 144-145° C.

Provenance & Evidence