1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 58236947, compound

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Reaction Steps

To an ice-cooled and stirred mixture of (2-{7-methoxy-5-[4-(methylsulfonyl)phenoxy]-1H-indol-2-yl}-4,5-dihydro-1,3-thiazol-5-yl)acetic acid (80 mg) in N,N-dimethylformamide (10 mL) were added 1-hydroxybenzotriazole ammonium salt (53 mg) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (67 mg). After stirring at 4° C. to room temperature for 15 h, the reaction mixture was partitioned between ethyl acetate and water. The organic layer was washed successively with aqueous sodium hydrogen carbonate solution and brine, dried (MgSO4), filtered, and concentrated to give a pale yellow oil, which was crystallized from ethyl acetate-hexane to give the title compound (72 mg, 91%) as colorless crystals. MS 460 (MH+). mp 169-170° C.

Provenance & Evidence