참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydroxylamine | HCID 787 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Methylbenzonitrile | HCID 10721 | — |
| 반응물 | Dichloromethane methanol | HCID 21226129 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-Hydroxy-2-methyl-benzamidine | HCID 3098087 | 100% |
반응 단계
A mixture of 2-methyl-benzonitrile (0.950 mL, 8 mmol), hydroxylamine 50% in water (1.6 mL, 24 mmol) and EtOH (8 mL) was heated at 70° C. for 48h. TLC analysis (DCM/MeOH: 97/3 as eluent) indicates the completion of the reaction. The solvent was removed under reduced pressure to afford 1.2 g of N′-hydroxy-2-methylbenzamidine (Yield: 100%) as a white powder (M.P.=147-148.5° C.). which can be used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08674106B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_03 |
|---|
| ORD ID | ord-edc21b54462a45ffa676bf21da886008 |
|---|
| 출처 메모 | uspto-grants-2014_03 |
|---|
