HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Trimethylsilyl)prop-1-yne → HCID 66598684, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Trimethylsilyl)prop-1-yne | HCID 80363 | — |
| Reactant | 1H-Benzimidazole, 2-(chloromethyl)-1-(2-phenylethyl)- | HCID 4559487 | — |
| Product | HCID 66598684 | HCID 66598684 | 102.4% |
Reaction Steps
The title compound was prepared in accordance with the general method of Example 191(D), from of 2-(chloromethyl)-1-phenethyl-1H-benzo[d]imidazole (500 mg, 1.8 mmol) and trimethyl(prop-1-ynyl)silane (249 mg, 2.22 mmol). 1-phenethyl-2-(4-(trimethylsilyl)but-3-ynyl)-1H-benzo[d]imidazole (639 mg, Yield: 100%) was obtained as a brown oil which was used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674106B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-2d0f8e094e6e47a3a84aa3d73983ade1 |
| Source note | uspto-grants-2014_03 |