Thionyl Chloride → HCID 21976873, compound

Participants

Reaction Steps

To a solution of OBS02015 (3.93 g, 10.10 mmol) in anhydrous DCM (50 mL) was added thionyl chloride (1.11 mL, 15.15 mmol). The mixture was stirred at room temperature for 2 h and the volatiles removed in vacuo. The residue was re-dissolved and co-evaporated three times with DCM (3×20 mL) to give OBS02018 as a brown oil which solidified on standing (3.93 g, 96%). TLC [SiO2, EtOAc-n-hexane (1:1)] Rf=0.83; 1H-NMR (270 MHz, CDCl3)=3.11 (6H, s), 4.46 (2H, s), 7.59 (2H, s). Dimethylsulfamic Acid 2,6-dibromo-4-{[(4-cyano-phenyl)-[1,2,4]triazol-4-ylamino]methyl}phenyl ester (OBS02019, STX740)

Provenance & Evidence