HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-6-(fluoromethyl)pyridine → HCID 66597910, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-6-(fluoromethyl)pyridine | HCID 10241610 | — |
| Reactant | 2-(But-3-yn-1-yl)-1,3-benzothiazole | HCID 57053628 | — |
| Product | HCID 66597910 | HCID 66597910 | 38.6% |
Reaction Steps
The title compound was prepared in accordance with the general method of Example 190(F), from 2-bromo-6-(fluoromethyl)pyridine (266 mg, 1.40 mmol) and 2-(but-3-ynyl)benzo[d]thiazole (compound 35(A), 260 mg, 1.40 mmol). The crude residue was purified over silicagel chromatography (prepacked 25 g silicagel column, Cyclohexane/AcOEt: from 100/0 to 80/20 as eluent) to afford 160 mg of 2-(4-(6-(fluoromethyl)pyridin-2-yl)but-3-ynyl)benzo[d]thiazole (Yield: 38%) as a beige powder (Mp=74-76° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674106B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-1392f5e386794f4887efc2a3ea45dc15 |
| Source note | uspto-grants-2014_03 |