HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Iodopyridine → 2-(4-(Pyridin-2-yl)but-3-ynyl)isoindoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Iodopyridine | HCID 221126 | — |
| Reactant | N-(3-Butynyl)phthalimide | HCID 11171619 | — |
| Product | 2-(4-(Pyridin-2-yl)but-3-ynyl)isoindoline-1,3-dione | HCID 11644791 | 45% |
Reaction Steps
The title compound was prepared in accordance with the general method of Example 1, from 2-iodopyridine (453 mg, 2.21 mmol) and 2-(but-3-ynyl)isoindoline-1,3-dione (400 mg, 2.01 mmol, Example 189(B)). The crude residue was purified by flash chromatography (cyclohexane/AcOEt 70:30) to yield 250 mg (0.90 mmol, 45%) of 2-(4-(pyridin-2-yl)but-3-ynyl)isoindoline-1,3-dione as.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674106B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-d82280b882394a20a014162ac90475b5 |
| Source note | uspto-grants-2014_03 |