Nitrogen → HCID 49838063, compound

Participants

Reaction Conditions

Reaction Steps

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of a mixture of 2-(5-acetyl-thiophen-2-ylmethyl)-oxazole-4-carbonyl azide and 2-[5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-ylmethyl]-oxazole-4-carbonyl azide (138 mg) in xylene (0.5 mL) was heated to 140° C. for 5 min. 2-chlorobenzyl alcohol (144 mg, 1.00 mmol) was then added and the reaction mixture was further stirred at 140° C. for 5 min. The solvent was removed under reduced pressure. Purification of the residue by FC (20:1→1:1 hept-EA) followed by preparative HPLC gave the title compound as a white solid. LC-MS-conditions 07: tR=1.50 min, [M+H]+=391.10.

Provenance & Evidence