Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | HCID 58575185 | HCID 58575185 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 58575609 | HCID 58575609 | 105.3% |
Reaction Steps
To a mixed liquid of 4.70 g of methyl 4-amino-2-(methoxymethyl)-5-nitrobenzoate, 750 mg of ammonium chloride, 47.0 mL of tetrahydrofuran, 94.0 mL of methanol, and 14.0 mL of water was added 7.65 g of reduced iron, followed by stirring at 80° C. overnight. After cooling to room temperature, the insoluble materials were filtered through celite and the filtrate was evaporated under reduced pressure to obtain 4.33 g of methyl 4,5-diamino-2-(methoxymethyl)benzoate as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08674096B2 |
|---|
| Source dataset | uspto-grants-2014_03 |
|---|
| ORD ID | ord-eafa177f3dfd43d8a545603c8d2782e0 |
|---|
| Source note | uspto-grants-2014_03 |
|---|
