HCID 58575158, compound → HCID 58575262, compound

HRID 1189463Notes

Reaction equation

HRID 1189463 reaction equation
[C:1]([O:4][CH:5]([CH:16]1[CH2:18][CH2:17]1)[C:6]([O:8]CC1C=CC=CC=1)=[O:7])(=[O:3])[CH3:2]>CO>[C:1]([O:4][CH:5]([CH:16]1[CH2:17][CH2:18]1)[C:6]([OH:8])=[O:7])(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 58575158HCID 58575158, compound

Product 1

HCID 58575262HCID 58575262, compoundYield 130.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.40 g of benzyl acetoxy(cyclopropyl)acetate was added to 280 mL of methanol, followed by filtration. The filtrate was subjected to reduction using a continuous hydrogenation reactor (H-Cube (registered trademark); manufactured by ThalesNano) under the condition of CatCart (registered trademark), 10% palladium on carbon (manufactured by ThalesNano), a flow rate of 1.0 ml/min, and a pressure of 4 bar (Full H2 mode). The solvent was evaporated under reduced pressure to obtain 1.16 g of acetoxy(cyclopropyl)acetic acid.

Workup

  1. filtrationfollowed by filtration
  2. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-94ef46b609934ea8a14c828fb06093ec
Source dataset
uspto-grants-2014_03
Patent number
US08674096B2

Reaction notes

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