HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylsilane → ethyl 2-(5-cyclohexyl-2-methyl-3-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | Trimethylsilyl triflate | HCID 65367 | — |
| Reactant | 2-(Pyrrolidin-1-ylsulfonyl)benzaldehyde | HCID 57384582 | — |
| Reactant | ethyl 2-(2-cyclohexyl-5-methyl-1H-pyrrol-1-yl)acetate | HCID 67237997 | — |
| Product | ethyl 2-(5-cyclohexyl-2-methyl-3-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate | HCID 53247598 | 34% |
Reaction Steps
was followed using ethyl 2-(2-cyclohexyl-5-methyl-1H-pyrrol-1-yl)acetate (1.00 g, 4.01 mmol), triethylsilane (1.92 mL, 12.0 mmol), trimethylsilyl trifluoromethanesulfonate (1.45 mL, 8.02 mmol) and 2-(pyrrolidin-1-ylsulfonyl)benzaldehyde (0.960 g, 4.01 mmol) to afford ethyl 2-(5-cyclohexyl-2-methyl-3-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate (642 mg, 1.36 mmol, 34% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674115B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-b88bfaa949fc468f85afaa37b7f13420 |
| Source note | uspto-grants-2014_03 |