Dimethylformamide → ethyl 2-(3-cyano-2-cyclohexyl-5-methyl-4-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate

Participants

Reaction Steps

General procedure II was followed using ethyl 2-(5-cyclohexyl-2-methyl-3-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate (642 mg, 1.36 mmol), chlorosulfonyl isocyanate (0.147 mL, 1.70 mmol) and N,N-dimethylformamide (0.105 mL, 1.36 mmol) to afford ethyl 2-(3-cyano-2-cyclohexyl-5-methyl-4-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate (485 mg, 0.975 mmol, 72% yield) as a white sticky foam.

Provenance & Evidence