Triethylsilane → ethyl 2-(5-cyclopropyl-2-methyl-3-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate

Participants

Reaction Steps

was followed using 2-(2-cyclopropyl-5-methyl-1H-pyrrol-1-yl)acetate (1.25 g, 6.03 mmol), triethylsilane (2.89 mL, 18.1 mmol), trimethylsilyl trifluoromethanesulfonate (2.18 mL, 12.1 mmol) and 2-(pyrrolidin-1-ylsulfonyl)benzaldehyde (1.44 g, 6.03 mmol) to afford ethyl 2-(5-cyclopropyl-2-methyl-3-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate (642 mg, 1.49 mmol, 25% yield) as an oil.

Provenance & Evidence