Lithium hydroxide, monohydrate → 2-(3-cyano-2-cyclopropyl-5-methyl-4-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetic acid

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Reaction Steps

was followed using ethyl 2-(3-cyano-2-cyclopropyl-5-methyl-4-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate (65.4 mg, 0.144 mmol) and lithium hydroxide hydrate (12.05 mg, 0.287 mmol) to afford 2-(3-cyano-2-cyclopropyl-5-methyl-4-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetic acid as a white solid (58.5 mg, 0.137 mmol, 95% yield). 1H NMR (400 MHz, CDCl3) δ (ppm) 7.94 (d, 1H), 7.43 (dd, 1H), 7.32 (dd, 1H), 7.08 (d, 1H), 4.69 (s, 2H), 4.26 (s, 2H), 3.31-3.35 (m, 4H), 1.90-1.95 (m, 7H), 1.65 (m, 1H), 0.86-0.97 (m, 4H).

Provenance & Evidence