Hydrochloric Acid → 2-(2-methyl-4,5-diphenyl-3-(2-(phenylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetic acid

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Reaction Steps

Ethyl 2-(2-methyl-4,5-diphenyl-3-(2-(phenylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate (0.300 g, 0.546 mmol) was dissolved in a 3:1:1 mixture of THF/MeOH/water (10 ml) and charged with lithium hydroxide (0.065 g, 2.73 mmol). The reaction was stirred at rt for 1 h, at which time LC/MS suggested the reaction was complete. The reaction was acidified with 3 N HCl, and the resulting mixture concentrated to almost dryness (water left), diluted with 3 mL brine solution and extracted 3 times with DCM. The organic layers were combined, dried, filtered, and concentrated under vacuum to yield 2-(2-methyl-4,5-diphenyl-3-(2-(phenylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetic acid (285 mg, 0.546 mmol, 100% yield).

Provenance & Evidence