HRID1189562

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1c(Cc2ccccc2S(=O)(=O)c2ccccc2)c(-c2ccccc2)c(-c2ccccc2)n1CC(=O)O

HCID53246027

未命名化合物

HCID57384582

未命名化合物

PRODUCTS

生成物

结构：Cc1c(Cc2ccccc2S(=O)(=O)N2CCCC2)c(-c2ccccc2)c(-c2ccccc2)n1CC(=O)O

HCID53246028

未命名化合物

PROCEDURE

实验过程

2-(2-methyl-4,5-diphenyl-3-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetic acid was synthesized according to 2-(2-methyl-4,5-diphenyl-3-(2-(phenylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetic acid using 2-(pyrrolidin-1-ylsulfonyl)benzaldehyde in the general procedure I (step 1). 1H NMR (CDCl3/400 MHz) δ (ppm) 8.00 (d, 1H), 7.50-7.45 (m, 1H), 7.34-7.24 (m, 5H), 7.19-7.16 (m, 2H), 7.05-7.00 (m, 3H), 6.92-6.88 (m, 2H), 4.65 (s, 2H), 4.21 (s, 2H), 3.15 (t, 4H), 2.10 (s, 3H), 1.69-1.65 (m, 4H). MS m/z: 515.34 (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e7e53c4506c84a26aae9c3529f3d20ca
来源数据集: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08674115B2
来源说明: uspto-grants-2014_03

反应 SMILES

[CH3:1][C:2]1[N:3]([CH2:35][C:36]([OH:38])=[O:37])[C:4]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[C:5]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:6]=1CC1C=CC=CC=1S(C1C=CC=CC=1)(=O)=O.[N:39]1([S:44]([C:47]2[CH:54]=[CH:53][CH:52]=[CH:51][C:48]=2[CH:49]=O)(=[O:46])=[O:45])[CH2:43][CH2:42][CH2:41][CH2:40]1>>[CH3:1][C:2]1[N:3]([CH2:35][C:36]([OH:38])=[O:37])[C:4]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)=[C:5]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:6]=1[CH2:49][C:48]1[CH:51]=[CH:52][CH:53]=[CH:54][C:47]=1[S:44]([N:39]1[CH2:43][CH2:42][CH2:41][CH2:40]1)(=[O:46])=[O:45]