Trifluoroacetic acid → HCID 53246497, compound

Participants

Reaction Conditions

Reaction Steps

2-(2-methyl-3-(2-(morpholinosulfonyl)benzyl)-5-phenyl-4-(2,2,2-trifluoro-1-hydroxyethyl)-1H-pyrrol-1-yl)acetic acid (0.063 g, 0.114 mmol) was dissolved in 2 mL DCM and cooled to 0° C. 2,2,2-trifluoroacetic acid (1 ml, 0.114 mmol) was then added followed by triethylsilane (0.2 ml, 1.252 mmol). LC/MS shows reduction was instantly complete. The reaction mixture was directly concentrated to yield ˜5 mg of crude material, which was purified by preparative HPLC chromatography to give 18 mg (29.4%) of the desired material.

Provenance & Evidence