Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 2-(Morpholine-4-sulfonyl)benzoic acid | HCID 13140207 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 13140214 | HCID 13140214 | 113.2% |
Reaction Steps
To a slurry of 2-(morpholinosulfonyl)benzoic acid (327 mg, 1.21 mmol) in dichloromethane (11 mL) was added thionyl chloride (0.220 mL, 3.01 mmol). The reaction was heated at 60° C. for 1 hour, after which LCMS analysis (sodium methoxide solution, 25% in methanol) revealed reaction completion. The reaction was concentrated to afford 2-(morpholinosulfonyl)benzoyl chloride (0.397 g, 1.37 mmol) as a viscous yellow residue and this was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08674115B2 |
|---|
| Source dataset | uspto-grants-2014_03 |
|---|
| ORD ID | ord-fd60846647054ad18eb2d58bcbe80704 |
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| Source note | uspto-grants-2014_03 |
|---|
