HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1189611Generated: October 31, 2026
Sulfuric Acid → N-(3-Nitro-2,4-dichloro-benzyl)-2,2,2-trifluoroacetamide
https://huagongshe.com/reaction/1189611
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 1,3-Dichloro-2-nitrobenzene | HCID 11759 | — |
| Reactant | 2,2,2-Trifluoro-N-(hydroxymethyl)acetamide | HCID 3084931 | — |
| Product | N-(3-Nitro-2,4-dichloro-benzyl)-2,2,2-trifluoroacetamide | HCID 56839981 | — |
Reaction Steps
N-(Hydroxymethyl)trifluoroacetamide (6.6 mmol; 0.946 g) is added to a mixture of 2,6-dichloro-nitrobenzene (0.899 mL; 6.6 mmol) and conc H2SO4 (15 mL) at 75° C. The mixture is stirred at 75° C. overnight, poured into ice water and stirred for 1 h. The precipitate is collected by filtration and dried. Yield 0.32 g (15%). MS [M−H]−=315, HPLC-method B: Rt=1.43 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08674113B2 |
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| Source dataset | uspto-grants-2014_03 |
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| ORD ID | ord-f56965c710d34569b80d7a5362cc6b82 |
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| Source note | uspto-grants-2014_03 |
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