反应详情

A mixture of N-(3-nitro-2,4-dichloro-benzyl)-2,2,2-trifluoroacetamide (0.66 g, impure, content ˜50%), 4M NaOH-solution (1.3 mL, 5.2 mmol) and MeOH (15 mL) is refluxed for 4 h. Then the mixture is concentrated, diluted with water, acidified with 4M HCl, filtered, 4M NaOH-solution is added and it is extracted with EtOAc. The organic phase is dried with Na2SO4, filtered and concentrated. Yield 0.17 g

1. temperatureis refluxed for 4 h
2. concentrationThen the mixture is concentrated
3. additiondiluted with water
4. filtrationfiltered
5. addition4M NaOH-solution is added
6. extractionit is extracted with EtOAc
7. dry with materialThe organic phase is dried with Na2SO4
8. filtrationfiltered
9. concentrationconcentrated