反应详情

A mixture of N-(3-amino-2,4-difluoro-benzyl)-2,2-dimethyl-propionamide (570 mg, 2.35 mmol), 1,1′-thiocarbonyldi-2(1H)-pyridone (550 mg, 2.35 mmol) and dioxane (20 mL) is stirred at reflux overnight. The reaction mixture is concentrated, diluted with DCM, filtered through a pad of silica gel and the filtrate is concentrated to give the title compound.

1. temperatureat reflux overnight
2. concentrationThe reaction mixture is concentrated
3. additiondiluted with DCM
4. filtrationfiltered through a pad of silica gel
5. concentrationthe filtrate is concentrated