反应详情

Acetylchloride (2.56 mL, 36.0 mmol) is added to a mixture of 6-chloro-2-fluoro-3-methyl-aniline (5.00 g, 31.3 mmol) and toluene (200 mL), additional toluene (50 mL) is added and the mixture is heated to reflux for 3 h. Then it is cooled with an ice bath and the formed precipitate is filtered off, washed with cold toluene and dried.

1. additionis added
2. temperaturethe mixture is heated
3. temperatureto reflux for 3 h
4. temperatureThen it is cooled with an ice bath
5. filtrationthe formed precipitate is filtered off
6. washwashed with cold toluene
7. customdried