O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 67957366, compound

Participants

Role	Name	HCID	Charge
Reactant	O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate	HCID 2733207	—
Reactant	3,3,3-Trifluoro-2,2-dimethylpropanoic acid	HCID 19867367	—
Reactant	3-(Aminomethyl)-2,6-dichloroaniline	HCID 56839968	—
Product	HCID 67957366	HCID 67957366	—

Reaction Conditions

Temperature	45 °C

Reaction Steps

A mixture of 2-trifluoromethyl-isobutyric acid (2.85 mg, 18 mmol), 3-amino-2,4-dichloro-benzylamine (3.49 g, 18 mmol), TBTU (5.98 g, 19 mmol), TEA (7.7 mL, 55 mmol) and 65 mLTHF is stirred at 45° C. overnight. The mixture is washed with sat aq NaHCO3-solution and water and the organic phase is dried with Na2SO4, filtered, concentrated and purified by chromatography (silicagel, Cyclohexane:EtOAc 11:1→7:3).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08674113B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-ec7ddb427cb846f4be638c7cb72e6512
Source note	uspto-grants-2014_03