1,1'-Thiocarbonyldi-2(1H)-pyridone → HCID 86666462, compound

HRID 1189628Notes

Reaction equation

HRID 1189628 reaction equation
[C:1](N1C=CC=CC1=O)(N1C=CC=CC1=O)=[S:2].[NH2:17][C:18]1[C:19]([Cl:36])=[C:20]([CH:32]=[CH:33][C:34]=1[Cl:35])[CH2:21][NH:22][C:23](=[O:31])[C:24]([CH3:30])([C:26]([F:29])([F:28])[F:27])[CH3:25]>O.O1CCOCC1>[Cl:36][C:19]1[C:18]([N:17]=[C:1]=[S:2])=[C:34]([Cl:35])[CH:33]=[CH:32][C:20]=1[CH2:21][NH:22][C:23](=[O:31])[C:24]([CH3:30])([C:26]([F:27])([F:28])[F:29])[CH3:25]

Participants

5

Reactant 2

HCID 8531621,1'-Thiocarbonyldi-2(1H)-pyridoneHCID 67957366HCID 67957366, compound

Product 1

HCID 86666462HCID 86666462, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent2×

Procedure

1,1′-Thiocarbonyldi-2-pyridone (3.12 g, 13 mmol) is added to a mixture of N-(3-amino-2,4-dichloro-benzyl)-2-methyl-2-trifluoromethyl-propionamide (3.90 g, 11.8 mmol) and dioxane (135 mL) and stirred at reflux overnight. The mixture is diluted with water, most of the dioxane is removed under reduced pressure and the resulting precipitate is filtered, washed with water and dried.

Workup

  1. temperatureat reflux overnight
  2. customis removed under reduced pressure
  3. filtrationthe resulting precipitate is filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-0d724f4eb58146159049c55015ea7c94
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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