HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-Fluoro-3-chloro-phenyl)-2-(4-fluoro-piperidinyl)-4-methylamino-5-nitro-benzoic acid amide → N-(4-Fluoro-3-chloro-phenyl)-2-(4-fluoro-piperidinyl)-4-methylamino-5-amino-benzoic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-Fluoro-3-chloro-phenyl)-2-(4-fluoro-piperidinyl)-4-methylamino-5-nitro-benzoic acid amide | HCID 67957338 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-Fluoro-3-chloro-phenyl)-2-(4-fluoro-piperidinyl)-4-methylamino-5-amino-benzoic acid amide | HCID 67957421 | — |
Reaction Steps
A mixture of N-(4-fluoro-3-chloro-phenyl)-2-(4-fluoro-piperidinyl)-4-methylamino-5-nitro-benzoic acid amide (90 mg, 0.21 mmol), Ra—Ni (30 mg) and THF (10 mL) is stirred under 50 psi H2-atmosphere for 4 h. The mixture is filtered, and the filtrate is concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674113B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-58c747ad0ed148e78695a39575a8a2ed |
| Source note | uspto-grants-2014_03 |