HCID 178482249, compound → HCID 178482248, compound

HRID 1189635Notes

Reaction equation

HRID 1189635 reaction equation
[F:1][C:2]([F:31])([F:30])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:29])[C:11]2[CH:16]=[C:15]([N+:17]([O-])=O)[C:14]([NH:20][CH3:21])=[CH:13][C:12]=2[NH:22][CH:23]2[CH2:26][C:25]([F:28])([F:27])[CH2:24]2)[CH2:5][CH2:4]1>[Pd].CO>[F:1][C:2]([F:30])([F:31])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:29])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH:20][CH3:21])=[CH:13][C:12]=2[NH:22][CH:23]2[CH2:24][C:25]([F:27])([F:28])[CH2:26]2)[CH2:5][CH2:4]1

Participants

4

Reactant 1

HCID 178482249HCID 178482249, compound

Product 1

HCID 178482248HCID 178482248, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of N-(trans-4-trifluoromethyl-cyclohexyl)-2-[3,3-difluoro-cyclobutylamino]-4-methylamino-5-nitro-benzoic acid amide (crude product from the reaction above), Pd/C (50 mg) and MeOH (10 ml) is stirred under 3 bar H2-atmosphere for 6 h. The mixture is filtered, and the filtrate is concentrated and directly used in the next step.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-80584acc7f8648ceb64b2479425cb949
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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