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Hydrochloric Acid → HCID 178482234、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 3-(Trifluoromethyl)pyrrolidine | HCID 5152159 | — |
| 反応物 | HCID 178482229 | HCID 178482229 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | HCID 178482234 | HCID 178482234 | — |
反応手順
A mixture of 3-trifluoromethyl-pyrrolidine×HCl (53 mg, 0.30 mmol), DIPEA (0.40 ml, 2.4 mmol), N-(trans-4-trifluoromethyl-cyclohexyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide (100 mg, 0.28 mmol) and MeCN (2 mL) is stirred for 4.5 h at reflux. Then the mixture is diluted with water and the formed precipitate is filtered, washed with water and dried
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08674113B2 |
| 出典データセット | uspto-grants-2014_03 |
| ORD ID | ord-6ebbb829a94b4f8086bb4cb2742af89e |
| 出典メモ | uspto-grants-2014_03 |