HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl-2-[3,3-difluoro-pyrrolidinyl]-4-methylamino-5-nitro-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3,3-Difluoropyrrolidine | HCID 2782827 | — |
| Reactant | Methyl 2-chloro-4-(methylamino)-5-nitrobenzoate | HCID 67957559 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Methyl-2-[3,3-difluoro-pyrrolidinyl]-4-methylamino-5-nitro-benzoate | HCID 67957632 | — |
Reaction Steps
The sub-title compound is prepared in analogy to procedure 6a from methyl-2-chloro-4-methylamino-5-nitro-benzoate (1.00 g, 4.09 mmol), 3,3-difluoro-pyrrolidine×HCl (880 mg, 6.13 mmol), DIPEA (2.8 mL, 16 mmol) and dioxane (10 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674113B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-9961ea978aff4fa4897786a12659325a |
| Source note | uspto-grants-2014_03 |