2,2-Difluoroethanamine → HCID 86666469, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,2-difluoroethylamine (1.65 mL, 23 mmol) and THF (50 mL) is added to a mixture of 2-chloro-4-fluoro-5-nitro-benzoic acid (5.00 g, 22 mmol), TEA (6.33 mL, 45 mmol) and 50 mL THF. The mixture is stirred overnight at rt and 30 h at 60° C., concentrated and diluted with water. The resulting precipitate is collected by filtration, washed with water and dried. Yield: 3.3 g (61%); HPLC Rt=1.14 min (method A). MS m/z: 281 [M+H]+.

Provenance & Evidence