HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3,3-Trifluoropropylamine → N-(3,3,3-Trifluoro-propyl)-2-chloro-4-methylamino-5-nitro-benzoic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3,3-Trifluoropropylamine | HCID 10001 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 2-Chloro-4-(methylamino)-5-nitrobenzoic acid | HCID 67957507 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(3,3,3-Trifluoro-propyl)-2-chloro-4-methylamino-5-nitro-benzoic acid amide | HCID 67957674 | — |
Reaction Steps
The sub-title compound is prepared in analogy to 5c from 2-chloro-4-methylamino-5-nitro-benzoic acid (900 mg, 3.9 mmol), 3,3,3-trifluoro-propylamine (0.58 g, 3.9 mmol), TBTU (1.38 g, 4.2 mmol), DIPEA (2.0 mL, 11.7 mmol) and THF (20 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674113B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-970837954e2b48e8964c1171e5ab8358 |
| Source note | uspto-grants-2014_03 |