反应详情

A mixture of N-(trans-4-trifluoromethyl-cyclohexyl)-2-chloro-4-methylamino-5-nitro-benzoic acid amide (60 mg, 0.158 mmol), N-methyl-propargylamine (79 μL, 0.95 mmol) and MeCN (10 mL) is irradiated in a microwave oven for 45 min at 160° C., and after cooling diluted with water. The mixture is extracted with EtOAc, the combined organic phases are dried with Na2SO4, filtered and concentrated.

1. customis irradiated in a microwave oven for 45 min at 160° C.
2. temperatureafter cooling
3. extractionThe mixture is extracted with EtOAc
4. dry with materialthe combined organic phases are dried with Na2SO4
5. filtrationfiltered
6. concentrationconcentrated