反应详情

A mixture of N-(trans-4-trifluoromethyl-cyclohexyl)-2-chloro-4-methylamino-5-nitro-benzoic acid amide (60 mg, 0.158 mmol), N-methyl-N-(4-fluorobenzyl)amine (24 μL, 0.18 mmol) and MeCN (1 mL) is irradiated in a microwave oven for 45 min at 160° C., and after cooling diluted with water. The mixture is extracted with EtOAc, the combined organic phases are dried with Na2SO4, filtered and concentrated and directly used in the next step. Yield: 80 mg.

1. customis irradiated in a microwave oven for 45 min at 160° C.
2. temperatureafter cooling
3. extractionThe mixture is extracted with EtOAc
4. dry with materialthe combined organic phases are dried with Na2SO4
5. filtrationfiltered
6. concentrationconcentrated